Devazepide

Name: Devazepide
Brand: Tocris Bioscience
SKU: 2304
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2304

(1)

Citations (61)

COA / SDS

Selective, orally active CCK1 receptor antagonist

Key Product Details

Description:	Selective, orally active CCK₁ receptor antagonist
Alternative Names:	L-364,718,MK 329
Chemical Name:	N-[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	408.46

View Full Technical Details for Devazepide

Technical Data
Citations / Reviews (1)

Biological Activity for Devazepide

Devazepide is a potent, orally active CCK₁ (CCK-A) receptor antagonist that displays appetite-stimulant effects. Blocks the anorectic response to CCK-8 and increases food intake in rats following systemic and i.c.v administration.

Technical Data for Devazepide

M. Wt	408.46
Formula	C₂₅H₂₀N₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	103420-77-5
PubChem ID	443375
InChi Key	NFHRQQKPEBFUJK-HSZRJFAPSA-N
Smiles	CN1C2=CC=CC=C2C(=N[C@H](NC(=O)C2=CC3=C(N2)C=CC=C3)C1=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Devazepide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.85	100
	ethanol	20.42	50

Preparing Stock Solutions for Devazepide

The following data is based on the product molecular weight 408.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.24 mL	24.48 mL
5 mM	0.49 mL	2.45 mL	4.90 mL
10 mM	0.24 mL	1.22 mL	2.45 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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Reconstitution Calculator

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References for Devazepide

References are publications that support the biological activity of the product.

Duca MetF. activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. Nat.Med. 2015 PMID: 25849133
Reidelberger Effects of peripheral CCK receptor blockade on food intake in rats. Am.J.Physiol.Reg.Integr.Comp.Physiol. 2003 PMID: 12738611
Ritter Increased food intake and CCK receptor antagonists: beyond abdominal vagal afferents. Am.J.Physiol.Reg.Integr.Comp.Physiol. 2004 PMID: 15142854
Ebenezer Effects of intracerebroventricular administration of the CCK1 receptor antagonist devazepide on food intake in rats. Eur.J.Pharmacol. 2002 PMID: 12007923