Delavirdine mesylate

Name: Delavirdine mesylate
Brand: Tocris Bioscience
SKU: 4149

Tocris Bioscience, part of Bio-Techne | Catalog # 4149

COA / SDS

Non-nucleoside reverse transcriptase inhibitor

Discontinued Product

4149 has been discontinued. View all RNA/DNA Polymerase Inhibitors products.

Key Product Details

Description:	Non-nucleoside reverse transcriptase inhibitor
Alternative Names:	U 90152
Chemical Name:	1-[3-[(1-Methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]-1H-indol-2-yl]carbonyl]-piperazine monomethanesulfonate
Purity:	≥99% (HPLC)
Molecular Weight:	552.67

View Full Technical Details for Delavirdine mesylate

Technical Data
Citations

Biological Activity for Delavirdine mesylate

Delavirdine mesylate is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC₅₀ values are 0.26, 440 and >550 μM for HIV-1 reverse transcriptase, DNA polymerase α and DNA polymerase δ). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active.

Licensing Information

Sold for research purposes under agreement from Viiv.

Compound Libraries for Delavirdine mesylate

Delavirdine mesylate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Delavirdine mesylate

M. Wt	552.67
Formula	C₂₂H₂₈N₆O₃S.CH₃SO₃H
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	147221-93-0
PubChem ID	441386
InChi Key	MEPNHSOMXMALDZ-UHFFFAOYSA-N
Smiles	O=C(N3CCN(C4=NC=CC=C4NC(C)C)CC3)C2=CC1=CC(NS(=O)(C)=O)=CC=C1N2.CS(O)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Delavirdine mesylate

References are publications that support the biological activity of the product.

Pagano and Chong In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavi. (U-90152) with protease inhibitor U-75875 or IF.-alpha. J.Infect.Dis. 1995 PMID: 7528253
Dueweke U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob.Agents Chemother. 1993 PMID: 7685995