Decanoyl-RVKR-CMK

Tocris Bioscience, part of Bio-Techne | Catalog # 3501

Subtilisin/Kex2p-like proprotein convertase inhibitor
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Key Product Details

Description

Subtilisin/Kex2p-like proprotein convertase inhibitor

View all Furin Inhibitors »

Product Description

Decanoyl-RVKR-CMK is a subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells. Inhibits cleavage of glycoprotein B of human cytomegalovirus. Also inhibits cleavage of SARS-CoV-2 spike protein by furin and blocks viral cell entry (IC50 = 57 nM in plaque reduction assay).

Product Specifications

Molecular Weight

744.42

Formula

C34H66ClN11O5

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

150113-99-8

PubChem ID

9962075

InChI Key

NHBJTTGFHCHQHS-VZTVMPNDSA-N

SMILES

[H]N([C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CCl)C(=O)CCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Product Documents for Decanoyl-RVKR-CMK

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Decanoyl-RVKR-CMK

For research use only

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