Deazaflavin, Alkyne

Product Description

Deazaflavin, Alkyne is a deazaflavin-based organic photocatalyst bearing a terminal alkyne functional group for use in bioorthogonal conjugation strategies such as copper-catalyzed azide-alkyne cycloaddition (CuAAC). Upon blue light illumination (~450 nm), the deazaflavin photocatalyst undergoes excitation and enables Dexter-type triplet energy transfer to nearby photoactivatable functional groups such as diazirines or aryl azides, leading to covalent labeling of proximal proteins or biomolecules. When tethered to a targeting ligand, peptide, or macromolecule via the alkyne handle, the reagent allows proximity-dependent photolabeling in live cells or complex biological environments.

Solubility

Preparing Stock Solutions for Deazaflavin, Alkyne

The following data is based on the product molecular weight 307.35

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.54 mL	162.68 mL	325.36 mL
0.5 mM	6.51 mL	32.54 mL	65.07 mL
1 mM	3.25 mL	16.27 mL	32.54 mL
5 mM	0.65 mL	3.25 mL	6.51 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Crocker Energy-transfer photoproximity labelling in live cells using an organic cofactor. Nat.Chem. 2025 PMID: 40962911