DCPIB

Product Description

DCPIB is a volume-regulated anion channel (VRAC) blocker (IC₅₀ ~ 2 μM in rat pancreatic β-cells). Also blocks I_Cl,swell in various cardiovascular tissues (IC₅₀ = 4.1 μM in CPAE cells). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect K_ATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro. Also activates TREK1 and TRAAK K⁺ channels and inhibits TRESK, TASK1 and TASK3 K⁺ channels at 10 μM, in vitro. Also inhibits VRAC-mediated 2'3'-cyclic-GMP-AMP (cGAMP) transport.

Solubility

Preparing Stock Solutions for DCPIB

The following data is based on the product molecular weight 427.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.34 mL	11.70 mL	23.40 mL
5 mM	0.47 mL	2.34 mL	4.68 mL
10 mM	0.23 mL	1.17 mL	2.34 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lahey LRRC8A:C/E heteromeric channels are ubiquitous transporters of cGAMP. Mol.Cell. 2020 PMID: 33171122
• Lv DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K_2P channels. ACS.Chem.Neurosci. 2019 PMID: 30935201
• Decher DCPIB is a novel selective blocker of I_Cl,swell and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br.J.Pharmacol. 2001 PMID: 11724753
• Best Inhibition of glucose-induced electrical activity in rat pancreatic β-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents. Eur.J.Pharmacol. 2004 PMID: 15063150
• Bourke Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with total inhibition by a non-diuretic acylaryloxyacid derivative. J.Neurosurg. 1981 PMID: 6267227