DCEBIO

Name: DCEBIO
Brand: Tocris Bioscience
SKU: 1422

Tocris Bioscience, part of Bio-Techne | Catalog # 1422

Citations (32)

COA / SDS

Activates Cl- conductance and hKCa3.1 channels

Key Product Details

Description:	Activates Cl- conductance and hKCa3.1 channels
Chemical Name:	5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Purity:	≥99% (HPLC)
Molecular Weight:	231.08

View Full Technical Details for DCEBIO

Technical Data
Citations

Biological Activity for DCEBIO

DCEBIO is a stimulates Cl^- secretion via the activation of hK_Ca3.1 (IK1) potassium channels and an apical Cl^- conductance carried by the CFTR channel. More potent than its analog 1-EBIO (Cat. No. 1041).

Compound Libraries for DCEBIO

DCEBIO is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DCEBIO

M. Wt	231.08
Formula	C₉H₈Cl₂N₂O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	60563-36-2
PubChem ID	656765
InChi Key	LKHRMULASXZCLG-UHFFFAOYSA-N
Smiles	CCN1C(=O)NC2=C1C=C(Cl)C(Cl)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DCEBIO

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.11	100
	ethanol	23.11	100

Preparing Stock Solutions for DCEBIO

The following data is based on the product molecular weight 231.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.33 mL	21.64 mL	43.28 mL
5 mM	0.87 mL	4.33 mL	8.66 mL
10 mM	0.43 mL	2.16 mL	4.33 mL
50 mM	0.09 mL	0.43 mL	0.87 mL

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References for DCEBIO

References are publications that support the biological activity of the product.

Hamilton and Kiessling DCEBIO stimulates Cl- secretion in the mouse jejunum. Am.J.Physiol.Cell Physiol. 2006 PMID: 16135545
Singh Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J.Pharmacol.Exp.Ther. 2001 PMID: 11160649