DC 260126

Name: DC 260126
Brand: Tocris Bioscience
SKU: 5357

Tocris Bioscience, part of Bio-Techne | Catalog # 5357

Citations (25)

COA / SDS

FFA1 (GPR40) antagonist

Key Product Details

Description:	FFA1 (GPR40) antagonist
Chemical Name:	N-(4-Butylphenyl)-4-fluorobenzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	307.38

View Full Technical Details for DC 260126

Technical Data
Citations

Biological Activity for DC 260126

DC 260126 is a free fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca²⁺ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats.

Compound Libraries for DC 260126

DC 260126 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DC 260126

M. Wt	307.38
Formula	C₁₆H₁₈FNO₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	346692-04-4
PubChem ID	2843133
InChi Key	CNGHPXKWPGIDSK-UHFFFAOYSA-N
Smiles	CCCCC(C=C2)=CC=C2NS(C1=CC=C(F)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DC 260126

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.74	100
	ethanol	30.74	100

Preparing Stock Solutions for DC 260126

The following data is based on the product molecular weight 307.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.25 mL	16.27 mL	32.53 mL
5 mM	0.65 mL	3.25 mL	6.51 mL
10 mM	0.33 mL	1.63 mL	3.25 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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References for DC 260126

References are publications that support the biological activity of the product.

Sun DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS ONE 2013 PMID: 23776696
Hu A novel class of antagonists for the FFAs receptor GPR40. Biochem.Biophys.Res.Comm. 2009 PMID: 19818732
Zhang DC260126, a small-molecule antagonist of GPR40, improves Ins tolerance but not glucose tolerance in obese Zucker rats. Biomed.Pharmacother. 2010 PMID: 20888730