DBeQ

Name: DBeQ
Brand: Tocris Bioscience
SKU: 4417
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4417

(1)

Citations (2)

COA / SDS

Selective and reversible p97 ATPase inhibitor

Discontinued Product

4417 has been discontinued. View all Other ER Stress/UPR Inhibitors products.

Key Product Details

Description:	Selective and reversible p97 ATPase inhibitor
Chemical Name:	N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine
Purity:	≥99% (HPLC)
Molecular Weight:	340.42

View Full Technical Details for DBeQ

Technical Data
Citations / Reviews (1)

Biological Activity for DBeQ

DBeQ is a selective and reversible inhibitor of p97 ATPase (VCP, IC₅₀ = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.

Compound Libraries for DBeQ

DBeQ is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DBeQ

M. Wt	340.42
Formula	C₂₂H₂₀N₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	177355-84-9
PubChem ID	676352
InChi Key	QAIMUUJJAJBPCL-UHFFFAOYSA-N
Smiles	C12=CC=CC=C1N=C(NCC4=CC=CC=C4)N=C2NCC3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for DBeQ

References are publications that support the biological activity of the product.

Chou and Deshaies Development of p97 AAA ATPase inhibitors. Autophagy 2011 PMID: 21606684
Chou Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc.Natl.Acad.Sci.USA 2011 PMID: 21383145