Darunavir
Tocris Bioscience, part of Bio-Techne | Catalog # 6710
Highly potent HIV protease inhibitor
Key Product Details
Description
Highly potent HIV protease inhibitor
Product Description
Darunavir is a highly potent HIV protease inhibitor (IC50 = 3 - 6 nM, depending on laboratory HIV-1 strain). Displays activity in cells infected with clinical HIV-1 strains shown to have resistance to other protease inhibitors.Tocris products are for biomedical research use only. They are not intended for human or veterinary use.
Product Specifications
Molecular Weight
547.66
Formula
C27H37N3O7S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamate
CAS Number
206361-99-1
PubChem ID
213039
InChI Key
CJBJHOAVZSMMDJ-HEXNFIEUSA-N
SMILES
[H][C@@]12CCO[C@@]1(OC[C@@H]2OC(N[C@H]([C@@H](CN(S(=O)(C3=CC=C(C=C3)N)=O)CC(C)C)O)CC4=CC=CC=C4)=O)[H]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.77 | 100 |
Preparing Stock Solutions
for Darunavir
The following data is based on the product molecular weight 547.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.83 mL | 9.13 mL | 18.26 mL |
| 5 mM | 0.37 mL | 1.83 mL | 3.65 mL |
| 10 mM | 0.18 mL | 0.91 mL | 1.83 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Koh Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob.Agents Chemother. 2003 PMID: 14506019
- Ghosh Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere. Bioorg.Med.Chem.Lett. 1998 PMID: 9871583
Product Specific Notices for Darunavir
For research use only
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