Dantrolene, sodium salt

Name: Dantrolene, sodium salt
Brand: Tocris Bioscience
SKU: 0507
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0507

(1)

Citations (36)

COA / SDS

Ca2+ release inhibitor

Key Product Details

Description:	Ca²⁺ release inhibitor
Chemical Name:	1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	336.23

View Full Technical Details for Dantrolene, sodium salt

Technical Data
Citations / Reviews (1)

Biological Activity for Dantrolene, sodium salt

Inhibits release of Ca²⁺ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.

Technical Data for Dantrolene, sodium salt

M. Wt	336.23
Formula	C₁₄H₉N₄NaO₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	14663-23-1
PubChem ID	6604100
InChi Key	KSRLIXGNPXAZHD-HAZZGOGXSA-M
Smiles	O=C([N-]3)N(CC3=O)/N=C/C1=CC=C(C2=CC=C([N+]([O-])=O)C=C2)O1.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dantrolene, sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.36	10

Preparing Stock Solutions for Dantrolene, sodium salt

The following data is based on the product molecular weight 336.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.74 mL	148.71 mL	297.42 mL
0.5 mM	5.95 mL	29.74 mL	59.48 mL
1 mM	2.97 mL	14.87 mL	29.74 mL
5 mM	0.59 mL	2.97 mL	5.95 mL

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Reconstitution Calculator

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References for Dantrolene, sodium salt

References are publications that support the biological activity of the product.

O'Mara Dantrolene inhibits long-term depression and depotentiation of synaptic transmission in the rat dentate gyrus. Neuroscience 1995 PMID: 8577362
Zhao Dantrolene inhibition of ryanodine receptor Ca²⁺ release channels. J.Biol.Chem. 2001 PMID: 11278295
Hotchkiss and Karl Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia. Proc.Natl.Acad.Sci.U.S.A. 1994 PMID: 8159702