[D-Trp⁸]-γ-MSH

Name: [D-Trp 8 ]-γ-MSH
Brand: Tocris Bioscience
SKU: 4272

Tocris Bioscience, part of Bio-Techne | Catalog # 4272

COA / SDS

Selective MC3 receptor agonist

Discontinued Product

4272 has been discontinued. View all Melanocortin Receptor Agonists products.

Key Product Details

Description:	Selective MC₃ receptor agonist
Molecular Weight:	1570.79

View Full Technical Details for [D-Trp⁸]-γ-MSH

Technical Data
Citations

Biological Activity for [D-Trp⁸]-γ-MSH

[D-Trp⁸]-γ-MSH is a selective melanocortin 3 (MC₃) receptor agonist (IC₅₀ values are 6.7, 340 and 600 nM for human MC₃, MC₅ and MC₄ receptors respectively). Displays anti-inflammatory efficacy.

Technical Data for [D-Trp⁸]-γ-MSH

M. Wt	1570.79
Formula	C₇₄H₉₉N₂₁O₁₆S
Single Letter Sequence	YVMGHFRWDRFG (Modifications: Trp-8 = D-Trp)
Storage	Store at -20°C
CAS Number	321351-81-9
PubChem ID	16157270
InChi Key	GZWUQPQBOGLSIM-MDMVXOTPSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for [D-Trp⁸]-γ-MSH

References are publications that support the biological activity of the product.

Getting [D-Trp⁸]-γ-Melanocyte-stimulating-hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol.Pharmacol. 2006 PMID: 16959942
Patel Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J. 2010 PMID: 20702773
Grieco D-amino acid scan of γ-melanocyte-stimulating hormone: importance of Trp⁸ on human MC3 receptor selectivity. J.Med.Chem. 2000 PMID: 11150170

[D-Trp⁸]-γ-MSH

Tocris Bioscience, part of Bio-Techne | Catalog # 4272

Key Product Details

Biological Activity for [D-Trp⁸]-γ-MSH

Technical Data for [D-Trp⁸]-γ-MSH

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for [D-Trp⁸]-γ-MSH

Product Documents for [D-Trp⁸]-γ-MSH

COA

Certificate of Analysis

SDS

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[D-Trp8]-γ-MSH

Tocris Bioscience, part of Bio-Techne | Catalog # 4272

Key Product Details

Biological Activity for [D-Trp8]-γ-MSH

Technical Data for [D-Trp8]-γ-MSH

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for [D-Trp8]-γ-MSH

Product Documents for [D-Trp8]-γ-MSH

COA

Certificate of Analysis

SDS

[D-Trp⁸]-γ-MSH

Biological Activity for [D-Trp⁸]-γ-MSH

Technical Data for [D-Trp⁸]-γ-MSH

References for [D-Trp⁸]-γ-MSH

Product Documents for [D-Trp⁸]-γ-MSH