[D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Name: [D-p-Cl-Phe 6 ,Leu 17 ]-VIP
Brand: Tocris Bioscience
SKU: 3054

Tocris Bioscience, part of Bio-Techne | Catalog # 3054

Citations (13)

COA / SDS

Selective VIP receptor antagonist

Key Product Details

Description:	Selective VIP receptor antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	3342.24

View Full Technical Details for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Technical Data
Citations

Biological Activity for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

[D-p-Cl-Phe⁶,Leu¹⁷]-VIP is a selective vasoactive intestinal peptide (VIP) receptor antagonist (IC₅₀ = 125.8 nM). Displays no activity on glucagon, secretin or GRF receptors.

Technical Data for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

M. Wt	3342.24
Formula	C₁₄₈H₂₃₉ClN₄₄O₄₂
Single Letter Sequence	HSDAVFTDNYTRLRKQLAVKKYLNSILN (Modifications: Phe-6 = p-Cl-D-Phe, Asn-34 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	102805-45-8
PubChem ID	90488798
InChi Key	BUTRVBZATBJGPP-BERWWWERSA-N
Smiles	[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC1=CC=C(Cl)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Solubility

Soluble to 1mg/ml in water

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References for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

References are publications that support the biological activity of the product.

Pozo Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur.J.Pharmacol. 1997 PMID: 9085051
Xie Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells. Mol.Pharmacol. 2007 PMID: 17430995
Pandol Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe⁶,Leu¹⁷]VIP. Am.J.Physiol. 1986 PMID: 2421587

[D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Tocris Bioscience, part of Bio-Techne | Catalog # 3054

Key Product Details

Biological Activity for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Technical Data for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Solubility for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

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Dilution Calculator

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References for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Product Documents for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

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[D-p-Cl-Phe6,Leu17]-VIP

Tocris Bioscience, part of Bio-Techne | Catalog # 3054

Key Product Details

Biological Activity for [D-p-Cl-Phe6,Leu17]-VIP

Technical Data for [D-p-Cl-Phe6,Leu17]-VIP

Solubility for [D-p-Cl-Phe6,Leu17]-VIP

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for [D-p-Cl-Phe6,Leu17]-VIP

Product Documents for [D-p-Cl-Phe6,Leu17]-VIP

COA

Certificate of Analysis

SDS

[D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Biological Activity for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Technical Data for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Solubility for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

References for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Product Documents for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP