D-GsMTx4

Tocris Bioscience, part of Bio-Techne | Catalog # 7170

TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion
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Key Product Details

Description

TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion

View all TRPC Channel Inhibitors »

Product Description

D-GsMTx4 is a TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusion model. Resistant to proteolytic digestion.

Licensing Information

Sold under license from The Research Foundation of The State University of New York

Product Specifications

Molecular Weight

4095.86

Formula

C185H273N49O45S6

Storage

Store at -20°C

Purity

≥95% (HPLC)

InChI Key

WVDNTWXIIKNMHY-CFGROZRMSA-N

SMILES

CC(C)C[C@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H]2CSSC[C@@H](NC(=O)CN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC3=CC=CC=C3)C(=O)N[C@H](CC3=CNC4=CC=CC=C34)C(=O)N[C@H](CC3=CNC4=CC=CC=C34)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]3CSSC[C@@H](NC(=O)[C@@H](CCCCN)NC1=O)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CSSC[C@@H](NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CC(N)=O)NC3=O)C(=O)N2)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@H](CO)C(=O)N[C@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for D-GsMTx4

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for D-GsMTx4

For research use only

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