D-Aspartic acid

Name: D -Aspartic acid
Brand: Tocris Bioscience
SKU: 0213

Tocris Bioscience, part of Bio-Techne | Catalog # 0213

Citations (2)

COA / SDS

NMDA agonist

Discontinued Product

0213 has been discontinued. View all NMDA Receptor Agonists products.

Key Product Details

Description:	NMDA agonist
Chemical Name:	D-Aminosuccinic acid
Molecular Weight:	133.1

View Full Technical Details for D-Aspartic acid

Technical Data
Citations

Biological Activity for D-Aspartic acid

D-Aspartic acid is an endogenous NMDA receptor agonist with similar activity to the L-isomer. Also a non-metabolizable substrate for EAA uptake systems. Modulates melatonin synthesis in the pineal gland.

L-isomer also available.

Technical Data for D-Aspartic acid

M. Wt	133.1
Formula	C₄H₇NO₄
Storage	Store at RT
CAS Number	1783-96-6
PubChem ID	83887
InChi Key	CKLJMWTZIZZHCS-UWTATZPHSA-N
Smiles	N[C@@]([H])([C@](O)=O)CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for D-Aspartic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		100

Preparing Stock Solutions for D-Aspartic acid

The following data is based on the product molecular weight 133.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	7.51 mL	37.57 mL	75.13 mL
5 mM	1.50 mL	7.51 mL	15.03 mL
10 mM	0.75 mL	3.76 mL	7.51 mL
50 mM	0.15 mL	0.75 mL	1.50 mL

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Reconstitution Calculator

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References for D-Aspartic acid

References are publications that support the biological activity of the product.

Ishio D-Aspartate modulates melatonin synthesis in rat pinealocytes. Neurosci.Lett. 1998 PMID: 9682837
Olverman Structure/activity relations of NMDA receptor ligands as studied by their inhibition of 3H-D-AP5 binding in rat brain membranes. Neuroscience 1988 PMID: 2901691
Hashimoto Free D-aspartate and D-serine in the mammalian brain and periphery. Prog.Neurobiol. 1997 PMID: 9247969