Cyprodime hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2601
Selective μ antagonist
Product Description
Cyprodime hydrochloride is a selective μ-opioid receptor antagonist (Ki values are 5.4, 244.6 and 2187 nM for μ-, δ- and κ-opioid receptors respectively). Reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.Product Specifications
Molecular Weight
391.93
Formula
C22H29NO3.HCl
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
17-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one hydrochloride
CAS Number
2387505-50-0
PubChem ID
71628324
InChI Key
MMOBYZBXXHEAAX-NCBCLDNOSA-N
SMILES
O=C3C[C@]24C1=C(OC)C=CC=C1C[C@@H](N(CC5CC5)CC4)[C@@](OC)2CC3.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.19 | 100 | |
| Ethanol | 39.19 | 100 |
Preparing Stock Solutions
for Cyprodime hydrochloride
The following data is based on the product molecular weight 391.93
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.76 mL | 25.51 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.10 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Marki μ-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPγs binding assays. Eur.J.Pharmacol. 1999 PMID: 10585536
- Henry μ- and δ-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Exp.Neurol. 2001 PMID: 11520128
- Schmidhammer Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime. J.Med.Chem. 1995 PMID: 7636870
Product Specific Notices for Cyprodime hydrochloride
For research use only
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