Cyclosomatostatin
Tocris Bioscience, part of Bio-Techne | Catalog # 3493
Non-selective sst antagonist
Key Product Details
Description
Non-selective sst antagonist
Alternative Names
Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL])
Product Description
Cyclosomatostatin is a non-selective somatostatin (sst) receptor antagonist. Blocks the effects of sst on airway β-adrenergic function, CRF-induced suppression of gastric empyting, modulation of ACh release and growth hormone, insulin and glucagon release. Reported to act as an sst receptor agonist in human neuroblastoma cell line SH-SY5Y.Product Specifications
Molecular Weight
779.98
Formula
C44H57N7O6
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
84211-54-1
PubChem ID
122080
InChI Key
YHVHQZYJGWGAKN-ZUWUZHNASA-N
SMILES
C[C@@H](OCC1=CC=CC=C1)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CCCCCCNC1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in 20% ethanol / water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Stirnweis The putative somatostatin antagonist, cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), may act as a potent antiproliferative agonist. Peptides 2002 PMID: 12182954
- Guo Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent segment in the rat. Brain Res. 2008 PMID: 18640104
- Fries Somatostatin antagonist analog increases GH, Ins, and glucagon release in the rat. Peptides 1982 PMID: 6129618
Product Specific Notices for Cyclosomatostatin
For research use only
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