Cyclophosphamide
Tocris Bioscience, part of Bio-Techne | Catalog # 4091
Alkylating agent; chemotherapeutic
Key Product Details
Description
Alkylating agent; chemotherapeutic
Product Description
Cyclophosphamide is a nitrogen mustard alkylating agent and prodrug. Phosphoramide mustard (active metabolite) forms DNA cross-links leading to cell death. Inhibits aldehyde dehydrogenase 1 (ALDH1) through its degradation product acrolein. Chemotherapeutic for the treatment of breast cancer; regulates Bax and Bcl-2 expression when administered with etoposide (Cat. No. 1226) in breast cancer cell lines.Product Specifications
Molecular Weight
261.09
Formula
C7H15Cl2N2O2P
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[bis(2-Chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
CAS Number
50-18-0
PubChem ID
2907
InChI Key
CMSMOCZEIVJLDB-UHFFFAOYSA-N
SMILES
O=P1(N(CCCl)CCCl)OCCCN1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.11 | 100 | |
| DMSO | 26.11 | 100 |
Preparing Stock Solutions
for Cyclophosphamide
The following data is based on the product molecular weight 261.09
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.83 mL | 19.15 mL | 38.30 mL |
| 5 mM | 0.77 mL | 3.83 mL | 7.66 mL |
| 10 mM | 0.38 mL | 1.92 mL | 3.83 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.77 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hengstler DNA strand breaks and DNA cross-links in peripheral mononuclear blood cells of ovarian cancer patients during chemotherapy with cyclophosphamide/carboplatin. Cancer Res.
- Ren Inhibition of human aldehyde dehydrogenase 1 by the 4-hydroxycyclophosphamide degradation product acrolein. Drug Metab.Disp.
- Gibson Regulation of BAX and BCL-2 expression in breast cancer cells by chemotherapy. Breast Cancer Research and Treatment 1999 PMID: 10481938
Product Specific Notices for Cyclophosphamide
For research use only
⚠ WARNING: This product can expose you to chemicals including Cyclophosphamide (anhydrous), which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
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