Cyclic Pifithrin-α hydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 3843
p53 inhibitor
Key Product Details
Description
p53 inhibitor
Alternative Names
Pifithrin-β
Product Description
Cyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.Product Specifications
Molecular Weight
349.29
Formula
C16H16N2S.HBr
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole hydrobromide
CAS Number
511296-88-1
PubChem ID
11515812
InChI Key
SGNCOAOESGSEOP-UHFFFAOYSA-N
SMILES
CC(C=C4)=CC=C4C1=CN(C2=C(S3)CCCC2)C3=N1.Br
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.93 | 100 |
Preparing Stock Solutions
for Cyclic Pifithrin-α hydrobromide
The following data is based on the product molecular weight 349.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.86 mL | 14.31 mL | 28.63 mL |
| 5 mM | 0.57 mL | 2.86 mL | 5.73 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.86 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pietrancosta Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies. Bioorg.Med.Chem.Lett. 2005 PMID: 15745797
- Zuco and Zunino Cyclic Pifithrin-α sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis. Neoplasia 2008 PMID: 18516295
- Barchechath Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-α. J.Med.Chem. 2005 PMID: 16190767
Product Specific Notices for Cyclic Pifithrin-α hydrobromide
For research use only
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