CY 09
Tocris Bioscience, part of Bio-Techne | Catalog # 6436
NLRP3 inhibitor; active in vivo
Product Description
CY 09 is a NLRP3 inhibitor (Kd = 500 nM); directly binds to ATP-binding motif of NLRP3 NACHT domain. Blocks NLRP3 inflammasome assembly and activation. Displays therapeutic effects on mouse models of cryopyrin-associated autoinflammatory syndrome (CAPS) and type 2 diabetes. Exhibits no activity for hERG (10 μM).Product Specifications
Molecular Weight
423.43
Formula
C19H12F3NO3S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid
CAS Number
1073612-91-5
PubChem ID
44561595
InChI Key
DJTINRHPPGAPLD-DHDCSXOGSA-N
SMILES
OC(C1=CC=C(C=C1)/C=C2SC(N(C/2=O)CC3=CC(C(F)(F)F)=CC=C3)=S)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.47 | 20 with gentle warming |
Preparing Stock Solutions
for CY 09
The following data is based on the product molecular weight 423.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.81 mL | 59.04 mL | 118.08 mL |
| 1 mM | 2.36 mL | 11.81 mL | 23.62 mL |
| 2 mM | 1.18 mL | 5.90 mL | 11.81 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jiang Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J.Exp.Med. 2017 PMID: 29021150
Product Specific Notices for CY 09
For research use only
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