CU CPT 22
Tocris Bioscience, part of Bio-Techne | Catalog # 4884
Selective TLR1/2 inhibitor
Product Description
CU CPT 22 is a selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.Licensing Information
Sold under license from the University of ColoradoProduct Specifications
Molecular Weight
362.37
Formula
C19H22O7
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3,4,6-Trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid hexyl ester
CAS Number
1416324-85-0
PubChem ID
71503400
InChI Key
UBQFTTUFRSSOHE-UHFFFAOYSA-N
SMILES
O=C1C(O)=CC(C(OCCCCCC)=O)=CC2=C1C(O)=C(O)C(OC)=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.24 | 100 |
Preparing Stock Solutions
for CU CPT 22
The following data is based on the product molecular weight 362.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.76 mL | 13.80 mL | 27.60 mL |
| 5 mM | 0.55 mL | 2.76 mL | 5.52 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.76 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cheng Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angew Chem.Int.Ed.Engl. 2012 PMID: 22969053
Product Specific Notices for CU CPT 22
For research use only
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