CTAP

Tocris Bioscience, part of Bio-Techne | Catalog # 1560

COA / SDS

Potent and selective μ antagonist

Key Product Details

Description:	Potent and selective μ antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1104.32

View Full Technical Details for CTAP

Technical Data
Citations

Biological Activity for CTAP

CTAP is a potent and selective μ opioid receptor antagonist (IC₅₀ = 3.5 nM). Displays > 1200-fold selectivity over δ opioid and somatostatin receptors. Brain penetrant and active in vivo.

Technical Data for CTAP

M. Wt	1104.32
Formula	C₅₁H₆₉N₁₃O₁₁S₂
Single Letter Sequence	FCYWRTXT (Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, X = Pen, Disulfide bridge: 2-7, Thr-8 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	103429-32-9
PubChem ID	90479802
InChi Key	OFMQLVRLOGHAJI-KOFBULAQSA-N
Smiles	[H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC(C)(C)C(NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CTAP

Solubility

Soluble to 1mg/ml in water

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References for CTAP

References are publications that support the biological activity of the product.

Kramer Novel peptidic mu opioid antagonists: pharmacologic characterization in vitro and in vivo. J.Pharmacol.Exp.Ther. 1989 PMID: 2566679
Pelton Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for μ opioid receptors. J.Med.Chem. 1986 PMID: 2878079
Abbruscato Blood-brain barrier permeability and bioavailability of a highly potent and μ-selective opioid receptor antagonist, CTAP: comparison with mor. J.Pharmacol.Exp.Ther. 1997 PMID: 8996221