CTA 056
Tocris Bioscience, part of Bio-Techne | Catalog # 4726
ITK inhibitor
Product Description
CTA 056 is an interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC50 values are 0.1, 0.4 and 5 μM for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice.Product Specifications
Molecular Weight
554.68
Formula
C35H34N6O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1,5-Dihydro-7-(phenylmethyl)-1-[3-(1-piperidinyl)propyl]-2-[4-(4-pyridinyl)phenyl]-6H-imidazo[4,5-g]quinoxalin-6-one
CAS Number
1265822-30-7
PubChem ID
49870925
InChI Key
BSSBAJKNZOHHCA-UHFFFAOYSA-N
SMILES
O=C2C(CC7=CC=CC=C7)=NC1=CC3=C(N=C(C5=CC=C(C6=CC=NC=C6)C=C5)N3CCCN4CCCCC4)C=C1N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.55 | 10 with gentle warming |
Preparing Stock Solutions
for CTA 056
The following data is based on the product molecular weight 554.68
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.03 mL | 90.14 mL | 180.28 mL |
| 0.5 mM | 3.61 mL | 18.03 mL | 36.06 mL |
| 1 mM | 1.80 mL | 9.01 mL | 18.03 mL |
| 5 mM | 0.36 mL | 1.80 mL | 3.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for CTA 056
For research use only
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