CST 967
Tocris Bioscience, part of Bio-Techne | Catalog # 7801
Potent and selective USP7 Degrader (PROTAC®)
Key Product Details
Description
Potent and selective USP7 Degrader (PROTAC®)
Product Description
CST 967 is a potent and selective ubiquitin specific protease 7 (USP7) Degrader (PROTAC®; Dmax = 85% at 1μM, DC50 = 17 nM).PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
927.07
Formula
C51H58N8O9
Storage
Store at -20°C
Purity
≥96% (HPLC)
Chemical Name
3-(1-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbonyl)piperidin-4-yl)-N-(3-((4-hydroxy-1-((R)-3-phenylbutanoyl)piperidin-4-yl)methyl)-4-oxo-3,4-dihydroquinazolin-7-yl)propanamide
CAS Number
3093667-09-2
PubChem ID
170836153
InChI Key
REPLCRNGGWSKTN-JYQLQLLISA-N
SMILES
O=C1CCC(C(N1)=O)N2C(C3=C(C2=O)C=CC(N4CCC(CC4)C(N5CCC(CC5)CCC(NC6=CC(N=CN7CC8(CCN(CC8)C(C[C@H](C9=CC=CC=C9)C)=O)O)=C(C=C6)C7=O)=O)=O)=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 92.71 | 100 |
Preparing Stock Solutions
for CST 967
The following data is based on the product molecular weight 927.07
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.08 mL | 5.39 mL | 10.79 mL |
| 5 mM | 0.22 mL | 1.08 mL | 2.16 mL |
| 10 mM | 0.11 mL | 0.54 mL | 1.08 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Murgai Targeting the deubiquitinase USP7 for degradation with PROTACs. Chem.Commun. 2022 PMID: 35852517
Product Specific Notices for CST 967
For research use only
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