CST 626
Tocris Bioscience, part of Bio-Techne | Catalog # 8021
Potent pan IAP Degrader (PROTAC®)
Product Description
CST 626 is a potent IAP Degrader (PROTAC®) (DC50 values at 16 hours are 0.7 nM, 2.4 nM and 6.2 nM at XIAP, cIAP1 and cIAP2 respectively; Dmax = 90-99%). Reduces cell viability in some cell types, including SUDHL6 and MOLM13 (IC50 values are 16 nM and 21 nM respectively).PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
1103.43
Formula
C61H82N8O9S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S,4S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-4-(3-((5-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentyl)oxy)phenoxy)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide
CAS Number
3033993-13-1
InChI Key
SMENADKMMXTZAZ-FMVATYOPSA-N
SMILES
O=C([C@H]1N(C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)C[C@@H](OC3=CC(OCCCCC(N[C@H](C(N4C[C@H](O)C[C@H]4C(N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)C(C)(C)C)=O)=CC=C3)C1)N[C@@H]7CCCC8=CC=CC=C87
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 110.34 | 100 |
Preparing Stock Solutions
for CST 626
The following data is based on the product molecular weight 1103.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.91 mL | 4.53 mL | 9.06 mL |
| 5 mM | 0.18 mL | 0.91 mL | 1.81 mL |
| 10 mM | 0.09 mL | 0.45 mL | 0.91 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.18 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ng Heterobifunctional ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins. J.Med.Chem. 2023 PMID: 36996313
Product Specific Notices for CST 626
For research use only
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