CST 530
Tocris Bioscience, part of Bio-Techne | Catalog # 8065
Monovalent IAP antagonist
Product Description
CST 530 is a monovalent IAP antagonist. Induces cIAP1 and cIAP2 autodegradation in MM.1S cells (degrades cIAP1 at 0.1μM and cIAP2 at 1μM, after 16h). CST 530 reduces cell viability in a variety of cancer cell lines including SUDHL6, MOLM13 and HEL (IC50 values are 170 nM, 420 nM and 450 nM respectively).Product Specifications
Molecular Weight
560.74
Formula
C33H44N4O4
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
(2S,4S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-4-phenoxy-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide
CAS Number
847137-53-5
InChI Key
GUOVHJVNYPRNQS-SHUILBLCSA-N
SMILES
CN[C@@H](C)C(N[C@@H](C1CCCCC1)C(N2[C@@H](C[C@@H](C2)OC3=CC=CC=C3)C(N[C@H]4C5=CC=CC=C5CCC4)=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 56.07 | 100 |
Preparing Stock Solutions
for CST 530
The following data is based on the product molecular weight 560.74
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.78 mL | 8.92 mL | 17.83 mL |
| 5 mM | 0.36 mL | 1.78 mL | 3.57 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.78 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ng Heterobifunctional ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins. J.Med.Chem. 2023 PMID: 36996313
Product Specific Notices for CST 530
For research use only
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