CRID3 sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 5479
Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production
Key Product Details
Description
Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production
Alternative Names
CP-456773,MCC 950
Product Description
CRID3 sodium salt is a potent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1β, IL-18 and IL-1α production (IC50 values are 7.2, 10.3 and 12-18 nM, respectively). Selective for NLRP3 over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.Licensing Information
Sold for research purposes under agreement from Pfizer IncProduct Specifications
Molecular Weight
426.46
Formula
C20H23N2NaO5S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
CAS Number
256373-96-3
PubChem ID
91826093
InChI Key
LFQQNXFKPNZRFT-UHFFFAOYSA-M
SMILES
O=C(N(S(C4=CC(C(C)(O)C)=CO4)(=O)=O)[Na])NC1=C3C(CCC3)=CC2=C1CCC2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 42.65 | 100 | |
| DMSO | 42.65 | 100 |
Preparing Stock Solutions
for CRID3 sodium salt
The following data is based on the product molecular weight 426.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.34 mL | 11.72 mL | 23.45 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.69 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.34 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Coll MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nat.Chem.Biol. 2019 PMID: 31086327
- Tapia-Abellán MCC950 closes the active conformation of NLRP3 to an inactive state. Nat.Chem.Biol. 2019 PMID: 31086329
- Coll A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat.Med. 2015 PMID: 25686105
- Gordon Inflammasome inhibition prevents a-synuclein pathology and dopaminergic neurodegeneration in mice. Sci.Transl.Med. 2018 PMID: 30381407
- Laliberte Glutathione S-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing. J.Biol.Chem. 2003 PMID: 12624100
Product Specific Notices for CRID3 sodium salt
For research use only
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