CRF (human, rat)

Name: CRF (human, rat)
Brand: Tocris Bioscience
SKU: 1151

Tocris Bioscience, part of Bio-Techne | Catalog # 1151

Citations (29)

COA / SDS

Stimulates ACTH release

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Technical Data
Citations

Product Description
Licensing Information
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Stimulates ACTH release

Alternative Names

Corticotropin-Releasing Factor (human,rat)

View all Non-selective CRF Receptor Agonists »

Product Description

CRF (human, rat) is a endogenous peptide agonist for the CRF receptor (K_i values are 11, 44 and 38 nM for hCRF₁, rCRF_2a and mCRF_2b respectively). Stimulates the synthesis and release of ACTH from the anterior pituitary.

Licensing Information

Sold with the permission of the SALK Institute

Product Specifications

Molecular Weight

4758.00

Formula

C₂₀₈H₃₄₄N₆₀O₆₃S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

86784-80-7

PubChem ID

16132357

InChI Key

VXFVFWFSJFSXHN-FAUHKOHMSA-N

SMILES

[H]N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1.1mg/ml in water

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Vale Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of cortico. and β-endorphin. Science 1981 PMID: 6267699
Perrin Comparison of an agonist, urocortin, and an antagonist, astressin, as radioligands for characterization of corticotropin-releasing factor receptors. J.Pharmacol.Exp.Ther. 1999 PMID: 9918582
Tache Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor. Science 1983 PMID: 6415815
Souza Corticotropin-releasing factor receptors in rat forebrain: autoradiographic identification. Science 1984 PMID: 6328656
Rivier Mediation by cortico. releasing factor (CRF) of adenohypophysial hormone secretion. Annu.Rev.Physiol. 1986 PMID: 2871808
Perrin and Vale Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 1999 PMID: 10816663