CP 94253 hydrochloride

Name: CP 94253 hydrochloride
Brand: Tocris Bioscience
SKU: 1317

Catalog # 1317 | Tocris Bioscience a Bio-Techne Brand

Citations (7)

COA / SDS

Potent and selective 5-HT1B agonist

Key Product Details

Description:	Potent and selective 5-HT_1B agonist
Chemical Name:	5-Propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	293.8

View Full Technical Details for CP 94253 hydrochloride

Technical Data
Citations (7) / Reviews

Biological Activity for CP 94253 hydrochloride

CP 94253 hydrochloride is a potent, selective 5-HT_1B agonist (K_i values are 89, 2, 860, 49 and 1,600 nM for 5-HT_1A, 5-HT_1B, 5-HT_1C, 5-HT_1D and 5-HT₂ receptors respectively). Centrally active upon systemic administration in vivo.

Compound Libraries for CP 94253 hydrochloride

CP 94253 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CP 94253 hydrochloride

M. Wt	293.8
Formula	C₁₅H₁₉N₃O.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	845861-39-4
PubChem ID	11652258
InChi Key	PIIOXKQIZCVXMD-UHFFFAOYSA-N
Smiles	Cl.CCCOC1=CC=C2NC=C(C2=N1)C1=CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 94253 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	7.34	25
	DMSO	29.38	100

Preparing Stock Solutions for CP 94253 hydrochloride

The following data is based on the product molecular weight 293.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.40 mL	17.02 mL	34.04 mL
5 mM	0.68 mL	3.40 mL	6.81 mL
10 mM	0.34 mL	1.70 mL	3.40 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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References for CP 94253 hydrochloride

References are publications that support the biological activity of the product.

Knobelman Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT_1A and 5-HT_1B receptors. J.Pharmacol.Exp.Ther. 2000 PMID: 10688630
Fish Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253. Psychopharmacology 1999 PMID: 10550489
Koe Biochemical and behavioral studies of the 5-HT_1B receptor agonist, CP-94,253. Drug Dev.Res.

Citations for CP 94253 hydrochloride (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for CP 94253 hydrochloride include:

Gadgaard & Jensen (2020) Functional characterization of 5-HT_1A and 5-HT_1B serotonin receptor signaling through G-protein-activated inwardly rectifying K⁺ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol. 175
PMID: 32088264
Mansari et al. (2015) Effects of acute and sustained administration of Vort. on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Neuron. 232:2343
PMID: 25665528
Doslikova et al. (2013) 5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated. J Neurosci. 33:9800
PMID: 23739976
Eriksson et al. (2013) Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Psychopharmacology (Berl). 18:1096
PMID: 23032875
Hagan et al. (2012) 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse. 66:1024
PMID: 22961814
McDevitt et al. (2011) Serotonin 1B autoreceptors originating in the caudal dorsal raphe nucleus reduce expression of fear and depression-like behavior. Pain. 69:780
PMID: 21353664
Heisler et al. (2006) Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Biol Psychiatry. 51:239
PMID: 16846858

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