CP 673451
Tocris Bioscience, part of Bio-Techne | Catalog # 5993
Potent and selective PDGFR inhibitor
Key Product Details
Description
Potent and selective PDGFR inhibitor
Product Description
CP 673451 is a potent and selective PDGFR inhibitor (IC50 values are 1 and 10 nM for PDGFR-β and -α respectively). Selective for PDGFR kinase over a range of related kinases. Inhibits PDGFR-β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 673451 is reviewed on the Chemical Probes website.Product Specifications
Molecular Weight
417.50
Formula
C24H27N5O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
CAS Number
343787-29-1
PubChem ID
10158940
InChI Key
DEEOXSOLTLIWMG-UHFFFAOYSA-N
SMILES
COCCOC1=CC=C2N(C3=NC4=C(C=C3)C=CC=C4N5CCC(CC5)N)C=NC2=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.35 | 20 |
Preparing Stock Solutions
for CP 673451
The following data is based on the product molecular weight 417.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.98 mL | 59.88 mL | 119.76 mL |
| 1 mM | 2.40 mL | 11.98 mL | 23.95 mL |
| 2 mM | 1.20 mL | 5.99 mL | 11.98 mL |
| 10 mM | 0.24 mL | 1.20 mL | 2.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Roberts Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res. 2005 PMID: 15705896
Product Specific Notices for CP 673451
For research use only
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