CP 465022 hydrochloride

Name: CP 465022 hydrochloride
Brand: Tocris Bioscience
SKU: 2932

Tocris Bioscience, part of Bio-Techne | Catalog # 2932

COA / SDS

Selective and non-competitive AMPA antagonist

Key Product Details

Description:	Selective and non-competitive AMPA antagonist
Chemical Name:	3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	499.41

View Full Technical Details for CP 465022 hydrochloride

Technical Data
Citations

Biological Activity for CP 465022 hydrochloride

CP 465022 hydrochloride is a selective, non-competitive AMPA antagonist (IC₅₀ = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity. Also significantly blocks the persistent component of Na_v1.6 channel activity. Brain penetrant and orally active.

Technical Data for CP 465022 hydrochloride

M. Wt	499.41
Formula	C₂₆H₂₄ClFN₄O.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1785666-59-2
PubChem ID	53251536
InChi Key	YKYDGCRJPYLXHY-GVYCEHEKSA-N
Smiles	O=C2N(C3=CC=CC=C3Cl)C(/C=C/C4=NC(CN(CC)CC)=CC=C4)=NC1=CC=C(F)C=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 465022 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.94	100

Preparing Stock Solutions for CP 465022 hydrochloride

The following data is based on the product molecular weight 499.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	10.01 mL	20.02 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for CP 465022 hydrochloride

References are publications that support the biological activity of the product.

Menniti CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo. Stroke 2003 PMID: 12511770
Welch Traditional AMPA receptor antagonists partially block Na_v1.6-mediated persistent current. Neuropharmacology 2008 PMID: 18687344
Lazaro Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology 2002 PMID: 11804610