CP 424174

Name: CP 424174
Brand: Tocris Bioscience
SKU: 6107

Tocris Bioscience, part of Bio-Techne | Catalog # 6107

COA / SDS

Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3

Discontinued Product

6107 has been discontinued. View all Cytokine Compounds products.

Key Product Details

Description:	Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3
Chemical Name:	N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	452.99

View Full Technical Details for CP 424174

Technical Data
Citations

Biological Activity for CP 424174

CP 424174 is an inhibitor of IL-1β post-translational processing (IC₅₀ = 210 nM). Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for CP 424174

M. Wt	452.99
Formula	C₂₂H₂₉ClN₂O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	210825-31-3
PubChem ID	9911728
InChi Key	YRSBLSHMKVQWHP-UHFFFAOYSA-N
Smiles	O=S(C1=CC(C(O)(C)C)=CC=C1)(NC(NC2=C(C(C)C)C=C(Cl)C=C2C(C)C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for CP 424174

References are publications that support the biological activity of the product.

Baldwin Inhibiting the inflammasome: a chemical perspective. J.Med.Chem. 2016 PMID: 26422006
Perregaux Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J.Pharmacol.Exp.Ther. 2001 PMID: 11561079