Cortistatin 14

Name: Cortistatin 14
Brand: Tocris Bioscience
SKU: 3374

Tocris Bioscience, part of Bio-Techne | Catalog # 3374

Citations (2)

COA / SDS

Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2

Key Product Details

Description:	Endogenous neuropeptide; binds sst₁ - sst₅, ghrelin receptor and MRGPRX2
Alternative Names:	CST-14
Purity:	≥95% (HPLC)
Molecular Weight:	1721.03

View Full Technical Details for Cortistatin 14

Technical Data
Citations

Biological Activity for Cortistatin 14

Cortistatin 14 (CST-14) is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Cortistatin 14 displays potency at all somatostatin receptors (sst₁ - sst₅) and prevents somatostatin-14 binding (IC₅₀ values are 0.09, 0.2, 0.3, 0.3 and 5 nM at sst₂, sst₄, sst₃, sst₅ and sst₁ receptors, respectively). Also a potent MRGPRX2 agonist (EC₅₀ = 25 nM in HEK293 cells) and binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.

Technical Data for Cortistatin 14

M. Wt	1721.03
Formula	C₈₁H₁₁₃N₁₉O₁₉S₂
Single Letter Sequence	PCKNFFWKTFSSCK (Modifications: Disulfide bridge: 2-13)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	193829-96-8
PubChem ID	16133803
InChi Key	DDRPLNQJNRBRNY-WYYADCIBSA-N
Smiles	[H]N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cortistatin 14

Solubility

Soluble to 0.7mg/ml in water

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References for Cortistatin 14

References are publications that support the biological activity of the product.

Robas MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. J.Biol.Chem. 2003 PMID: 12915402
Solinski Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 2014 PMID: 24867890
Fukusumi Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. 1997 PMID: 9125122
Spier and de Lecea Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. 2000 PMID: 11011067
Deghenghi Cortistatin, but not somatostatin, binds to GH secretagogue (GHS) receptors of the human pituitary gland. J.Endocrinol.Invest. 2001 PMID: 11227737