Cortistatin 14

Name: Cortistatin 14
Brand: Tocris Bioscience
SKU: 3374

Tocris Bioscience, part of Bio-Techne | Catalog # 3374

Citations (1)

COA / SDS

Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2

Alternative Names

CST-14

View all Additional Somatostatin Receptor Peptides »

Product Description

Cortistatin 14 (CST-14) is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Cortistatin 14 displays potency at all somatostatin receptors (sst₁ - sst₅) and prevents somatostatin-14 binding (IC₅₀ values are 0.09, 0.2, 0.3, 0.3 and 5 nM at sst₂, sst₄, sst₃, sst₅ and sst₁ receptors, respectively). Also a potent MRGPRX2 agonist (EC₅₀ = 25 nM in HEK293 cells) and binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.

Product Specifications

Molecular Weight

1721.03

Formula

C₈₁H₁₁₃N₁₉O₁₉S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

193829-96-8

PubChem ID

16133803

InChI Key

DDRPLNQJNRBRNY-WYYADCIBSA-N

SMILES

[H]N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 0.7mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Robas MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. J.Biol.Chem. 2003 PMID: 12915402
Solinski Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 2014 PMID: 24867890
Fukusumi Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. 1997 PMID: 9125122
Spier and de Lecea Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. 2000 PMID: 11011067
Deghenghi Cortistatin, but not somatostatin, binds to GH secretagogue (GHS) receptors of the human pituitary gland. J.Endocrinol.Invest. 2001 PMID: 11227737