CORM 3

Name: CORM 3
Brand: Tocris Bioscience
SKU: 5320

Tocris Bioscience, part of Bio-Techne | Catalog # 5320

Citations (3)

COA / SDS

Water-soluble carbon monoxide-releasing molecule

Key Product Details

Description:	Water-soluble carbon monoxide-releasing molecule
Alternative Names:	Carbon monoxide releasing molecule 3
Chemical Name:	Tricarbonylchloro(glycinato)ruthenium
Molecular Weight:	294.61

View Full Technical Details for CORM 3

Technical Data
Citations

Biological Activity for CORM 3

CORM 3 is a water-soluble carbon monoxide-releasing molecule. Suppresses thrombin-induced nitrite release in BV-2 microglia. Protects isolated rats hearts from reperfusion damage in vitro and is cardioprotective in a rat myocardial infarction model in vivo. Also prolongs survival of transplanted hearts in mice. Exhibits anti-inflammatory and vasorelaxant effects.

Technical Data for CORM 3

M. Wt	294.61
Formula	C₅H₄ClNO₅Ru
Storage	Store at -20°C
CAS Number	475473-26-8
PubChem ID	9817618
InChi Key	IMFIZOFAMSDJSP-UHFFFAOYSA-L
Smiles	[Cl-][Ru++]1([NH2]CC(=O)[O-]1)(C#[O])(C#[O])C#[O]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CORM 3

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	29.46	100

Preparing Stock Solutions for CORM 3

The following data is based on the product molecular weight 294.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.39 mL	16.97 mL	33.94 mL
5 mM	0.68 mL	3.39 mL	6.79 mL
10 mM	0.34 mL	1.70 mL	3.39 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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Reconstitution Calculator

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References for CORM 3

References are publications that support the biological activity of the product.

Sawle Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. Br.J.Pharmacol. 2005 PMID: 15880142
Foresti Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br.J.Pharmacol. 2004 PMID: 15148243
Filippo Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3). Naunyn Schmiedebergs Arch.Pharmacol. 2012 PMID: 22038495
Clark Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ.Res. 2003 PMID: 12842916
Bani-Hani Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3. J.Pharmacol.Exp.Ther. 2006 PMID: 16772536