COR 170
Tocris Bioscience, part of Bio-Techne | Catalog # 4756
Selective CB2 receptor inverse agonist
Discontinued Product
4756 has been discontinued.
View all Cannabinoid R2/CB2 Inverse Agonists products.
Key Product Details
Description
Selective CB2 receptor inverse agonist
Product Description
COR 170 is a selective inverse agonist of CB2 receptors (Ki values are 3.8 and >10,000 nM for CB2 and CB1, respectively).Product Specifications
Molecular Weight
468.63
Formula
C31H36N2O2
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
N-(Adamant-1-yl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydroquinoline-3-carboxamide
CAS Number
1048039-15-1
PubChem ID
25033736
InChI Key
MSJISJDTJJYBFT-UHFFFAOYSA-N
SMILES
O=C(C4=CN(CCCCC)C5=C(C=C(C6=CC=CC=C6)C=C5)C4=O)NC12CC(C3)CC(CC3C2)C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.37 | 20 | |
| Ethanol | 46.86 | 100 |
Preparing Stock Solutions
for COR 170
The following data is based on the product molecular weight 468.63
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.67 mL | 21.34 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Contartese A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury. Pharmacol.Res. 2012 PMID: 23036353
- Pasquini Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo. J.Med.Chem. 2008 PMID: 18680276
Product Specific Notices for COR 170
For research use only
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