Compound E New
Tocris Bioscience, part of Bio-Techne | Catalog # TB6476-RMU
Compound E synthesized to Ancillary Material Grade
Key Product Details
Description
Compound E synthesized to Ancillary Material Grade
Alternative Names
γ-Secretase Inhibitor XXI
Product Description
Compound E is a γ-secretase and notch pathway inhibitor. Compound E enhances growth inhibition, differentiation and migration of neuroblastoma cells when used in a combination with DAPT (Cat. No. 2634) and 13-cis RA. In combination with hLIF, CHIR 99021 (Cat. No. 4423) and SB 431542 (Cat. No. 1614), Compound E accelerates the induction of a homogeneous, self-renewing primitive neuroepithelium population from hESCs. Compound E is active in vitro and in vivo. Used in protocol to generate pancreatic beta cells from hPSCs (see below).For more information about how Compound E may be used, see our protocol: Generation of β cells from hPSCs
This product is Bio-Techne's ancillary Material Grade version of Compound E (Cat. No. 6476). Suitable for use in research and further manufacturing of cell therapies. Find out more about our Ancillary Material Grade product range.
Product Specifications
Molecular Weight
490.50
Formula
C27H24F2N4O3
Storage
Store at -20°C (± 5°C)
Purity
≥98%
Chemical Name
N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
CAS Number
209986-17-4
InChI Key
JNGZXGGOCLZBFB-IVCQMTBJSA-N
SMILES
C[C@@H](C(N[C@H]1N=C(C2=CC=CC=C2N(C1=O)C)C3=CC=CC=C3)=O)NC(CC4=CC(F)=CC(F)=C4)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Product Specific Notices for Compound E
For research use only
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