CMPD101

Tocris Bioscience, part of Bio-Techne | Catalog # 5642

Potent and selective GRK2/3 inhibitor
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Key Product Details

Description

Potent and selective GRK2/3 inhibitor

View all G Protein (Heterotrimeric) Inhibitors »

Product Description

CMPD101 is a potent and selective GRK2/3 inhibitor (IC50 values are 32 and 54 nM for GRK3 and GRK2, respectively). Exhibits selectivity for GRK2/3 over GRK1/5. Reduces DAMGO-induced desensitization and internalization of μ-opioid receptors.

Product Specifications

Molecular Weight

466.46

Formula

C24H21F3N6O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-[[[4-Methyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]methyl]amino]-N-[[2-(trifluoromethyl)phenyl]methyl]benzamide

CAS Number

865608-11-3

PubChem ID

11677079

InChI Key

WFOVEDJTASPCIR-UHFFFAOYSA-N

SMILES

CN1C(CNC2=CC(C(NCC3=CC=CC=C3C(F)(F)F)=O)=CC=C2)=NN=C1C4=CC=NC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.65 100
Ethanol 46.65 100

Preparing Stock Solutions for CMPD101

The following data is based on the product molecular weight 466.46

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.14 mL 10.72 mL 21.44 mL
5 mM 0.43 mL 2.14 mL 4.29 mL
10 mM 0.21 mL 1.07 mL 2.14 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Calculators

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Reconstitution Calculator

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Product Documents for CMPD101

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CMPD101

For research use only

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