CLP 257
Tocris Bioscience, part of Bio-Techne | Catalog # 5242
Selective KCC2 activator
Product Description
CLP 257 is a selective KCC2 K+-Cl- cotransporter activator (EC50 = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, as well as 55 other receptors. Enhances Cl- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury.Product Specifications
Molecular Weight
307.34
Formula
C14H14FN3O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone
CAS Number
1181081-71-9
PubChem ID
44188931
InChI Key
SKCADXVKQRCWTR-GHXNOFRVSA-N
SMILES
OC1=C(/C=C2/C(N=C(N3CCCCN3)S2)=O)C=CC(F)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.73 | 100 |
Preparing Stock Solutions
for CLP 257
The following data is based on the product molecular weight 307.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.25 mL | 16.27 mL | 32.54 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gagnon Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat.Med. 2013 PMID: 24097188
Product Specific Notices for CLP 257
For research use only
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