Clofarabine

Tocris Bioscience, part of Bio-Techne | Catalog # 2600

Deoxycytidine kinase (dCK) substrate
Discontinued Product
2600 has been discontinued. View all Kinase Substrates products.

Key Product Details

Description

Deoxycytidine kinase (dCK) substrate

View all Kinase Substrates »

Product Description

Clofarabine is a deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.

Product Specifications

Molecular Weight

303.68

Formula

C10H11ClFN5O3

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine

CAS Number

123318-82-1

PubChem ID

119182

InChI Key

WDDPHFBMKLOVOX-AYQXTPAHSA-N

SMILES

O[C@@H]1[C@@H](CO)O[C@@H](N(C=N3)C2=C3C(N)=NC(Cl)=N2)[C@H]1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.37 100

Preparing Stock Solutions for Clofarabine

The following data is based on the product molecular weight 303.68

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.46 mL 32.93 mL
5 mM 0.66 mL 3.29 mL 6.59 mL
10 mM 0.33 mL 1.65 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Clofarabine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Clofarabine

For research use only

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