Clocinnamox mesylate is a systemically active, irreversible μ-opioid receptor antagonist (apparent K_i values are 0.7, 1.9 and 5.7 nM for mouse μ, δ and κ receptors respectively).

Product Specifications

Molecular Weight

601.11

Formula

C₂₉H₂₉ClN₂O₄.CH₃SO₃H

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

14β-(p-Chlorocinnamoylamino)-7,8-dihydro-N-cyclopropylmethylmorphinone mesylate

CAS Number

117332-69-1

PubChem ID

90479744

InChI Key

XAXNKAGAUFXFDO-JVJDXIHNSA-N

SMILES

C[S](O)(=O)=O.[H][C@@]12OC3=C4C(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@]5(CCC2=O)NC(=O)C=CC1=CC=C(Cl)C=C1)=CC=C3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	60.11	100
	Ethanol	15.03	25

Preparing Stock Solutions for Clocinnamox mesylate

The following data is based on the product molecular weight 601.11

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.66 mL	8.32 mL	16.64 mL
5 mM	0.33 mL	1.66 mL	3.33 mL
10 mM	0.17 mL	0.83 mL	1.66 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Broadbear Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, β-funaltrexamine, and β-chlornaltrexamine. J.Pharmacol.Exp.Ther. 2000 PMID: 10945843
Burke Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu receptor binding in mice. J.Pharmacol.Exp.Ther. 1994 PMID: 7965787
Zernig Mechanism of clocinnamox blockade of opioid receptors: evidence from in vitro and ex vivo binding and behavioural assays. J.Pharmacol.Exp.Ther. 1996 PMID: 8858971
Aceto Very long-acting narcotic antagonists. The 14β-p-substituted cinnamoylaminomorphinones and their partial mu agonist codeinone relatives. Arzneimittelforschung 1989 PMID: 2547389

Clocinnamox mesylate

Tocris Bioscience, part of Bio-Techne | Catalog # 0898

Key Product Details

Description

Alternative Names

View all mu Opioid Receptor Agonists »

Product Description