Clemizole hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5371

TRPC5 blocker; also H1 antagonist
Discontinued Product
5371 has been discontinued. An alternative/replacement product is available: 6766. View all TRPC Channel Blockers products.

Key Product Details

Description

TRPC5 blocker; also H1 antagonist

View all TRPC Channel Blockers »

Product Description

TRPC5 channel blocker (IC50 values are 1.1, 6.4, 9.1, 11.3 and 26.5 μM for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histamine H1 receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model.

Product Specifications

Molecular Weight

362.30

Formula

C19H20ClN3. HCl

Storage

Desiccate at RT

Purity

≥99% (HPLC)

Chemical Name

1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride

CAS Number

1163-36-6

PubChem ID

14412

InChI Key

DNFMJYXRIMLMBZ-UHFFFAOYSA-N

SMILES

ClC(C=C4)=CC=C4CN2C(CN3CCCC3)=NC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 7.25 20
DMSO 18.11 50

Preparing Stock Solutions for Clemizole hydrochloride

The following data is based on the product molecular weight 362.30

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.52 mL 27.60 mL 55.20 mL
2.5 mM 1.10 mL 5.52 mL 11.04 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
25 mM 0.11 mL 0.55 mL 1.10 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Clemizole hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Clemizole hydrochloride

For research use only

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