CL 82198 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2632
Selective inhibitor of MMP-13
Key Product Details
Description
Selective inhibitor of MMP-13
Product Description
CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish.Product Specifications
Molecular Weight
338.83
Formula
C17H23N2O3.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride
CAS Number
1188890-36-9
PubChem ID
16760373
InChI Key
PIOACXKZWXHBRB-UHFFFAOYSA-N
SMILES
Cl.O=C(NCCCCN1CCOCC1)C1=CC2=CC=CC=C2O1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.88 | 100 | |
| DMSO | 25.41 | 75 |
Preparing Stock Solutions
for CL 82198 hydrochloride
The following data is based on the product molecular weight 338.83
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.95 mL | 14.76 mL | 29.51 mL |
| 5 mM | 0.59 mL | 2.95 mL | 5.90 mL |
| 10 mM | 0.30 mL | 1.48 mL | 2.95 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Borg IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75. Endocrine Abstr.
- Lisse PacT.-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A 2016 PMID: 27035978
- Chen Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc.
Product Specific Notices for CL 82198 hydrochloride
For research use only
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