Cl-4AS-1

Name: Cl-4AS-1
Brand: Tocris Bioscience
SKU: 3812

Tocris Bioscience, part of Bio-Techne | Catalog # 3812

Citations (8)

COA / SDS

Steroidal androgen receptor agonist

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Steroidal androgen receptor agonist

View all Androgen Receptor Agonists »

Product Description

Cl-4AS-1 is a potent steroidal androgen receptor agonist (IC₅₀ = 12 nM). Mimics the action of 5α-dihydrotestosterone (DHT). Transactivates the mouse mammary tumor virus (MMTV) promoter; represses MMP1 promoter activity. Inhibits 5α-reductase type I and II (IC₅₀ values are 6 and 10 nM respectively).

Product Specifications

Molecular Weight

441.01

Formula

C₂₆H₃₃ClN₂O₂

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)-N-(2-Chlorophenyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1,4,6a-trimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide

CAS Number

188589-66-4

PubChem ID

90488881

InChI Key

CTVXDPDUOKQBKZ-BLIBDJTASA-N

SMILES

O=C(NC1=CC=CC=C1Cl)[C@H]2CC[C@@]3([H])[C@]4([H])CC[C@@]5([H])N(C)C(C=C[C@]5(C)[C@@]4([H])CC[C@@]32C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	4.41	10
	Ethanol	4.41	10

Preparing Stock Solutions for Cl-4AS-1

The following data is based on the product molecular weight 441.01

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.68 mL	113.38 mL	226.75 mL
0.5 mM	4.54 mL	22.68 mL	45.35 mL
1 mM	2.27 mL	11.34 mL	22.68 mL
5 mM	0.45 mL	2.27 mL	4.54 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Schmidt Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J.Biol.Chem. 2009 PMID: 19846549
Tolman 4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-N-aryl-carboxamides: an approach to combined androgen blockade [5α-reductase inhibition with androgen receptor binding in vitro]. J.Steroid.Biochem.Mol.Biol. 1997 PMID: 9219921