CITFA

Name: CITFA
Brand: Tocris Bioscience
SKU: 7811

Tocris Bioscience, part of Bio-Techne | Catalog # 7811

COA / SDS

Potent G protein-coupled estrogen receptor (GPER) agonist

Key Product Details

Description:	Potent G protein-coupled estrogen receptor (GPER) agonist
Chemical Name:	N-[2-Cyclohexyl-4-(1-methylethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yl)-2-furanmethanamine
Purity:	≥98% (HPLC)
Molecular Weight:	381.56

View Full Technical Details for CITFA

Technical Data
Citations

Biological Activity for CITFA

CITFA is a potent GPER agonist (EC₅₀ = 38.7 nM). It significantly increases axonal and dendritic growth in rat embryonic (E18) hippocampal neurons.

Licensing Information

Sold under licence from Saint Louis University.

Compound Libraries for CITFA

CITFA is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CITFA

M. Wt	381.56
Formula	C₂₅H₃₅NO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2379989-52-1
PubChem ID	153360510
InChi Key	GYTVCHRGONLGMD-UHFFFAOYSA-N
Smiles	CC(C)C(C=C1C2CCCCC2)=CC=C1NCC3=CC=C(C4OCCCC4)O3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CITFA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	19.08	50
	ethanol	3.82	10

Preparing Stock Solutions for CITFA

The following data is based on the product molecular weight 381.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.24 mL	26.21 mL	52.42 mL
2.5 mM	1.05 mL	5.24 mL	10.48 mL
5 mM	0.52 mL	2.62 mL	5.24 mL
25 mM	0.10 mL	0.52 mL	1.05 mL

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References for CITFA

References are publications that support the biological activity of the product.

DeLeon Novel GPER agonist, CITFA, increases neurite growth in rat embryonic (E18) hippocampal neurons. ACS Chem.Neurosci. 2022 PMID: 35353510