CINPA 1
Tocris Bioscience, part of Bio-Techne | Catalog # 5605
Potent CAR antagonist
Discontinued Product
5605 has been discontinued.
View all Constitutive Androstane Receptor Antagonists products.
Key Product Details
Description
Potent CAR antagonist
Product Description
CINPA 1 is a potent CAR antagonist (IC50 = 70 nM). Exhibits >90-fold selectivity for CAR over pregnane X receptor (PXR). Also selective over a panel of other nuclear receptors including FXR, LXR, PPARγ and RXR.Product Specifications
Molecular Weight
395.49
Formula
C23H29N3O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate
CAS Number
102636-74-8
PubChem ID
969470
InChI Key
AYQBYSPEGRYKFA-UHFFFAOYSA-N
SMILES
O=C(CN(CC)CC)N1C2=C(C=CC=C2)CCC3=C1C=C(NC(OCC)=O)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.55 | 100 | |
| Ethanol | 39.55 | 100 |
Preparing Stock Solutions
for CINPA 1
The following data is based on the product molecular weight 395.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.64 mL | 25.29 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cherian CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol.Pharmacol. 2015 PMID: 25762023
Product Specific Notices for CINPA 1
For research use only
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