Cinacalcet hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 6170

Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable
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Key Product Details

Description

Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

Alternative Names

AMG 073

View all Calcium-Sensing Receptor Agonists »

Product Description

Cinacalcet hydrochloride is a calcium-sensing receptor (CaSR) allosteric agonist. Activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays. Reduces serum parathyroid hormone levels in rats. Also potent CYP2D2 inhibitor (IC50 = 87 nM) and L-type calcium channel blocker. Orally bioavailable.

Product Specifications

Molecular Weight

393.87

Formula

C22H22F3N.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride

CAS Number

364782-34-3

PubChem ID

156418

InChI Key

QANQWUQOEJZMLL-PKLMIRHRSA-N

SMILES

C[C@H](C1=CC=CC2=C1C=CC=C2)NCCCC3=CC(C(F)(F)F)=CC=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.39 100

Preparing Stock Solutions for Cinacalcet hydrochloride

The following data is based on the product molecular weight 393.87

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.69 mL 25.39 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Cinacalcet hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Cinacalcet hydrochloride

For research use only

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