Ciliobrevin A

Name: Ciliobrevin A
Brand: Tocris Bioscience
SKU: 4529
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4529

(1)

Citations (19)

COA / SDS

Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein

Discontinued Product

4529 has been discontinued. View all Hedgehog Signaling Inhibitors products.

Key Product Details

Description:	Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein
Alternative Names:	HPI-4
Chemical Name:	2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile
Purity:	≥98% (HPLC)
Molecular Weight:	358.18

View Full Technical Details for Ciliobrevin A

Technical Data
Citations / Reviews (1)

Biological Activity for Ciliobrevin A

Ciliobrevin A is a Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC₅₀ = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.

Technical Data for Ciliobrevin A

M. Wt	358.18
Formula	C₁₇H₉Cl₂N₃O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	302803-72-1
PubChem ID	6883982
InChi Key	SESYPWCSIZUIAS-FOWTUZBSSA-N
Smiles	O=C(C1=CC=CC=C1N2)N/C2=C(C(C3=C(Cl)C=C(Cl)C=C3)=O)\C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Ciliobrevin A

References are publications that support the biological activity of the product.

Firestone Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature 2012 PMID: 22425997
Hyman Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc.Natl.Acad.Sci.U.S.A. 2009 PMID: 19666565

Ciliobrevin A

Tocris Bioscience, part of Bio-Techne | Catalog # 4529

Key Product Details

Biological Activity for Ciliobrevin A

Technical Data for Ciliobrevin A

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Ciliobrevin A

Product Documents for Ciliobrevin A

COA

Certificate of Analysis

SDS

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