CID 2858522

Name: CID 2858522
Brand: Tocris Bioscience
SKU: 4246

Tocris Bioscience, part of Bio-Techne | Catalog # 4246

Citations (4)

COA / SDS

Selectively inhibits PKC-induced NF-κB activation

Discontinued Product

4246 has been discontinued. View all NFkB/IkB Inhibitors products.

Key Product Details

Description:	Selectively inhibits PKC-induced NF-κB activation
Chemical Name:	1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]ethanone
Purity:	≥98% (HPLC)
Molecular Weight:	465.63

View Full Technical Details for CID 2858522

Technical Data
Citations

Biological Activity for CID 2858522

CID 2858522 is a selectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway (IC₅₀ < 0.1 μM for PMA-stimulated IL-8 production). Inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. Does not inhibit other NF-κB pathways, including that activated by tumor necrosis factor (TNF).

Technical Data for CID 2858522

M. Wt	465.63
Formula	C₂₈H₃₉N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	758679-97-9
PubChem ID	2858523
InChi Key	CYCGGKILBWERDJ-UHFFFAOYSA-N
Smiles	OCCCNC2=NC1=CC(C)=C(C)C=C1N2CC(C3=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for CID 2858522

References are publications that support the biological activity of the product.

Shi Chemical biology strategy reveals pathway-selective inhibitor of NF-κB activation induced by protein kinase C and antigen receptors. ACS Chem.Bio.
Peddibhotla Inhibition of protein kinase C-driven NF-κB activation: synthesis, SAR, and pharmacological profiling of pathway specific benzimidazole probe molecules. J.Med.Chem. 2010 PMID: 20481485

CID 2858522

Tocris Bioscience, part of Bio-Techne | Catalog # 4246

Key Product Details

Biological Activity for CID 2858522

Technical Data for CID 2858522

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for CID 2858522

Product Documents for CID 2858522

COA

Certificate of Analysis

SDS

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