CID 2745687

Name: CID 2745687
Brand: Tocris Bioscience
SKU: 4293

Tocris Bioscience, part of Bio-Techne | Catalog # 4293

Citations (13)

COA / SDS

GPR35 antagonist

Key Product Details

Description:	GPR35 antagonist
Chemical Name:	1-(2,4-Difluorophenyl)-5-[[2-[[(1,1-dimethylehyl)amino]thioxomethyl]hydrazinylidene]methyl]-1H-pyrazole-4-carboxylic acid methyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	395.43

View Full Technical Details for CID 2745687

Technical Data
Citations

Biological Activity for CID 2745687

CID 2745687 is a competitive, reversible antagonist of the orphan receptor GPR35 (K_i = 12.8 nM). Blocks the GPR35-mediated increase in ERK1/2 phosphorylation and β-arrestin recruitment induced by pamoic acid.

Compound Libraries for CID 2745687

CID 2745687 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CID 2745687

M. Wt	395.43
Formula	C₁₇H₁₉F₂N₅O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	264233-05-8
PubChem ID	9581011
InChi Key	CYNLZIBKERMMOA-AWQFTUOYSA-N
Smiles	FC1=CC(F)=CC=C1N2C(/C=N/NC(NC(C)(C)C)=S)=C(C(OC)=O)C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CID 2745687

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.54	100
	ethanol	3.95	10

Preparing Stock Solutions for CID 2745687

The following data is based on the product molecular weight 395.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.64 mL	25.29 mL
5 mM	0.51 mL	2.53 mL	5.06 mL
10 mM	0.25 mL	1.26 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for CID 2745687

References are publications that support the biological activity of the product.

Jenkins Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 2012 PMID: 22967846
Zhao Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol.Pharmacol. 2010 PMID: 20826425