CID 16020046

Name: CID 16020046
Brand: Tocris Bioscience
SKU: 4959

Tocris Bioscience, part of Bio-Techne | Catalog # 4959

Citations (39)

COA / SDS

Selective GPR55 antagonist

Key Product Details

Description:	Selective GPR55 antagonist
Chemical Name:	4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	425.44

View Full Technical Details for CID 16020046

Technical Data
Citations

Biological Activity for CID 16020046

CID 16020046 is a selective GPR55 antagonist. Inhibits LPI-induced Ca²⁺ signaling (IC₅₀ = 0.21 μM in HEK-GPR55 cells), ERK1/2 phosphorylation and GPR55-mediated transcription factor activation. Displays weak inhibition of acetylcholinesterase, μ-opioid receptor, KCNH2 and hERG. Decreases LPI-induced GPR55 internalization. Reduces experimental intestinal inflammation in mice.

Compound Libraries for CID 16020046

CID 16020046 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CID 16020046

M. Wt	425.44
Formula	C₂₅H₁₉N₃O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	834903-43-4
PubChem ID	16020046
InChi Key	VGUQVYZXABOXCX-UHFFFAOYSA-N
Smiles	O=C1N(C5=CC=C(C(O)=O)C=C5)C(C4=CC=CC(O)=C4)C2=C1NN=C2C3=CC=C(C)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CID 16020046

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.54	100

Preparing Stock Solutions for CID 16020046

The following data is based on the product molecular weight 425.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.35 mL	11.75 mL	23.51 mL
5 mM	0.47 mL	2.35 mL	4.70 mL
10 mM	0.24 mL	1.18 mL	2.35 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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References for CID 16020046

References are publications that support the biological activity of the product.

Stančić The GPR55 antagonist CID16020046 protects against intestinal inflammation. Neurogastroenterol.Motil 2015 PMID: 26227635
Kargl A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. J.Pharmacol.Exp.Ther. 2013 PMID: 23639801