Ciclopirox

Name: Ciclopirox
Brand: Tocris Bioscience
SKU: 6384

Tocris Bioscience, part of Bio-Techne | Catalog # 6384

Citations (7)

COA / SDS

Pan-histone demethylase inhibitor

Key Product Details

Description:	Pan-histone demethylase inhibitor
Chemical Name:	6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone
Purity:	≥98% (HPLC)
Molecular Weight:	207.27

View Full Technical Details for Ciclopirox

Technical Data
Citations

Biological Activity for Ciclopirox

Ciclopirox is a pan-histone demethylase inhibitor. Exhibits no significant effect on histone deacetylases. Inhibits MYC-signaling and proliferation of neuroblastoma cells. Promotes Cdc25A-degradation in cancer cells. Antifungal.

Compound Libraries for Ciclopirox

Ciclopirox is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Ciclopirox

M. Wt	207.27
Formula	C₁₂H₁₇NO₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	29342-05-0
PubChem ID	2749
InChi Key	SCKYRAXSEDYPSA-UHFFFAOYSA-N
Smiles	CC1=CC(N(C(C2CCCCC2)=C1)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ciclopirox

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.73	100
	ethanol	20.73	100

Preparing Stock Solutions for Ciclopirox

The following data is based on the product molecular weight 207.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.82 mL	24.12 mL	48.25 mL
5 mM	0.96 mL	4.82 mL	9.65 mL
10 mM	0.48 mL	2.41 mL	4.82 mL
50 mM	0.10 mL	0.48 mL	0.96 mL

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Reconstitution Calculator

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References for Ciclopirox

References are publications that support the biological activity of the product.

Yang Targeting histone demethylases in MYC-driven neuroblastomas with ciclopirox. Cancer Res. 2017 PMID: 28684529
Shen Ciclopirox inhibits cancer cell proliferation by suppression of Cdc25A. Genes Cancer 2017 PMID: 28680535